The Use of Glycerol as an Enabling Excipient for Microwave-Induced In Situ Drug Amorphization

Microwave-induced in situ amorphization is a promising approach to circumvent stability and manufacturing issues associated with amorphous solid dispersions (ASD). Using amorphization, the crystalline state of drug converted into its form inside dosage form, e.g. compact, upon exposure microwave radiation. The study aimed investigate feasibility using glycerol as an enabling excipient compacts prepared from mixtures indomethacin Soluplus®. Additionally, possibility supersaturated ASD radiation due elevated temperatures was investigated. It found that i) acts dielectric heating source absorbing microwaves, ii) plasticizes polymer Soluplus® iii) increases solubility it fully ASDs could be achieved loadings below -, slightly above saturation Soluplus®/glycerol mixtures, after 20 min Hence, feasible for microwave-induced allowed preparation a, at room temperature, ASD, obtained during